Pcsk1 Gene Summary [Mouse]
Enables identical protein binding activity and serine-type endopeptidase activity. Involved in insulin processing and peptide biosynthetic process. Located in extracellular space. Is active in secretory granule. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; female reproductive system; and nose. Used to study endocrine system disease and obesity. Human ortholog(s) of this gene implicated in obesity and proprotein convertase 1/3 deficiency. Orthologous to human PCSK1 (proprotein convertase subtilisin/kexin type 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcsk1 |
| Official Name | proprotein convertase subtilisin/kexin type 1 [Source:MGI Symbol;Acc:MGI:97511] |
| Ensembl ID | ENSMUSG00000021587 |
| Bio databases IDs | |
| Aliases | proprotein convertase subtilisin/kexin type 1 |
| Synonyms | BDP, BMIQ12, DCE, Dyn-converting enzyme, NEC1, PC1, PC1/3, PC3, Phpp-1, proprotein convertase subtilisin/kexin type 1, SPC3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pcsk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase S8 pro-domain
- Subtilase family
- peptidase
- coiled-coil domain
- Prohormone convertase enzyme
- identical protein binding
- Peptidase domain in the S8 and S53 families
- endopeptidase
- serine endopeptidase
- transmembrane domain
- Proprotein convertase P-domain
- pro domain
- G-protein binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetes mellitus
- weight gain
- obesity
- hypogonadotropic hypogonadism
- dwarfism
- deficiency of proprotein convertase 1/3
- amenorrhea
- androgenic alopecia
- early-onset morbid obesity
phenotypes
- abnormal retinal blood vessel morphology
- abnormal retinal vasculature morphology
- abnormal vitreous body morphology
- decreased body length
- decreased mean corpuscular volume
- hypoactivity
- persistence of hyaloid vascular system
- preweaning lethality incomplete penetrance
- abnormal T-helper 1 cell differentiation
- abnormal body length
- abnormal glucose tolerance
- abnormal hormone level
- abnormal inguinal fat pad morphology
- abnormal locomotor activation
- abnormal mean corpuscular volume
- abnormal metabolism
- abnormal peritoneal macrophage morphology
- abnormal spleen marginal zone morphology
- abnormal spleen white pulp morphology
- chronic diarrhea
- decreased NK T cell number
- decreased T cell number
- decreased adrenocorticotropin level
- decreased body weight
- decreased circulating glucagon level
- decreased circulating growth hormone level
- decreased circulating insulin level
- decreased follicular dendritic cell number
- decreased mean systemic arterial blood pressure
- decreased skeletal muscle mass
- decreased testis weight
- diarrhea
- embryonic lethality before implantation complete penetrance
- enlarged spleen
- hypoglycemia
- impaired glucose tolerance
- increased body weight
- increased circulating interferon-gamma level
- increased circulating interleukin-1 beta level
- increased circulating interleukin-10 level
- increased circulating interleukin-12 level
- increased circulating interleukin-6 level
- increased circulating leptin level
- increased circulating tumor necrosis factor level
- increased interleukin-1 beta secretion
- increased lymphocyte cell number
- increased sensitivity to xenobiotic induced morbidity/mortality
- increased skeletal muscle mass
- increased susceptibility to diet-induced obesity
- increased susceptibility to endotoxin shock
- increased white adipose tissue amount
- insulin resistance
- intermingled spleen red and white pulp
- obese
- polyphagia
- postnatal lethality incomplete penetrance
- prenatal lethality incomplete penetrance
- reduced fertility
- slow postnatal weight gain
- transmission ratio distortion
role in cell
- number
- differentiation
- depletion
- accumulation
- abnormal morphology
- inactivation
- shrinkage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- Extracellular Space
- cell periphery
- perinuclear region
- granules
- cytosol
- endoplasmic reticulum lumen
- microsome
- trans Golgi network
- nerve ending
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- secretory granules
- perikaryon
- dendrites
- axon terminals
- premelanosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pcsk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin processing
- cell-cell signaling
- response to axon injury
- neurogenesis
- response to xenobiotic stimulus
- response to peptide hormone stimulus
- pituitary gland development
- response to glucose stimulus
- response to calcium ion
- proteolysis
- peptide biosynthetic process
- response to glucocorticoid stimulus
- response to interleukin-1
- response to lipopolysaccharide
- response to fatty acid
- protein autoprocessing
- positive regulation of protein secretion
- peptide hormone processing
- response to nutrient levels
- response to chlorate
- pancreas development
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular space
- trans-Golgi network
- perinuclear region of cytoplasm
- membrane
- secretory granule lumen
- transport vesicle
- perikaryon
- neuron projection
- axon terminus
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- serine-type endopeptidase activity