Itih2 Gene Summary [Mouse]
Predicted to enable hyaluronic acid binding activity. Predicted to be involved in hyaluronan metabolic process. Located in collagen-containing extracellular matrix. Is expressed in germ cell of testis; gut; liver; and meninges. Orthologous to human ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itih2 |
| Official Name | inter-alpha trypsin inhibitor, heavy chain 2 [Source:MGI Symbol;Acc:MGI:96619] |
| Ensembl ID | ENSMUSG00000037254 |
| Bio databases IDs | |
| Aliases | inter-alpha trypsin inhibitor, heavy chain 2 |
| Synonyms | H2P, HC2, I alpha I HC2, Inter-alpha inhibitor h2, inter-alpha trypsin inhibitor, heavy chain 2, inter-alpha-trypsin inhibitor heavy chain 2, Inter-α inhibitor h2, inter-α trypsin inhibitor, heavy chain 2, inter-α-trypsin inhibitor heavy chain 2, Intin2, ITI-HC2, I α I HC2, SHAP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Itih2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Inter-alpha-trypsin inhibitor heavy chain C-terminus
- endopeptidase inhibitor
- Vault protein inter-alpha-trypsin domain
- von Willebrand factor (vWF) type A domain
- vWFA
- von Willebrand factor type A domain
- protein binding
- hyaluronic acid binding
Pathways
Biological processes and signaling networks where the Itih2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic sinusitis
- non-insulin-dependent diabetes mellitus
- aortic valve calcification
role in cell
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- detergent resistant lipid raft fraction
- endoplasmic reticulum lumen
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Itih2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hyaluronan metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular vesicular exosome
- blood microparticle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- endopeptidase inhibitor activity
- protein binding
- hyaluronic acid binding