Med10 Gene Summary [Mouse]

Predicted to enable transcription coregulator activity. Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II and somatic stem cell population maintenance. Part of mediator complex. Is expressed in embryo; extraembryonic component; and tibialis anterior. Orthologous to human MED10 (mediator complex subunit 10). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Med10
Official Name
mediator complex subunit 10 [Source:MGI Symbol;Acc:MGI:106331]
Ensembl ID
ENSMUSG00000021598
Bio databases IDs NCBI: 28077 Ensembl: ENSMUSG00000021598
Aliases mediator complex subunit 10
Synonyms D13Wsu50e, L6, mediator complex subunit 10, NUT2, RGD1310128, TRG20
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Med10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • transcription regulator
  • ubiquitin protein ligase activity
  • protein binding
  • Transcription factor subunit Med10 of Mediator complex

Pathways

Biological processes and signaling networks where the Med10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • allergic rhinitis
regulated by
  • beta-estradiol
  • RGS2
regulates
  • DNA promoter
  • DNA endogenous promoter
  • RNA polymerase II

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Med10 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • positive regulation of transcription elongation from RNA polymerase II promoter
  • RNA polymerase II transcriptional preinitiation complex assembly
  • positive regulation of transcription initiation from RNA polymerase II promoter
  • positive regulation of transcription from RNA polymerase II promoter
  • protein ubiquitination

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • core mediator complex
  • ubiquitin ligase complex
  • mediator complex
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • transcription cofactor activity
  • protein binding

Gene-Specific Assays for Results You Can Trust

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