Med17 Gene Summary [Mouse]
Predicted to enable nuclear thyroid hormone receptor binding activity and transcription coactivator activity. Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within somatic stem cell population maintenance. Part of mediator complex. Is expressed in genitourinary system and limb mesenchyme. Human ortholog(s) of this gene implicated in infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly. Orthologous to human MED17 (mediator complex subunit 17). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Med17 |
| Official Name | mediator complex subunit 17 [Source:MGI Symbol;Acc:MGI:2182585] |
| Ensembl ID | ENSMUSG00000031935 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 17 |
| Synonyms | C330002H14Rik, CRSP6, CRSP77, DRIP77, DRIP80, mediator complex subunit 17, SRB4, TRAP80 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Med17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- ubiquitin protein ligase activity
- transcription cofactor
- protein binding
- thyroid hormone receptor binding
- Subunit 17 of Mediator complex
Pathways
Biological processes and signaling networks where the Med17 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- postnatal progressive microcephaly with seizures and brain atrophy
- asthma
- hereditary disorder
- productive infection by HIV-1
regulated by
- beta-estradiol
- arsenic trioxide
- Human herpesvirus 1 strain KOS
- laduviglusib
- imatinib
- TK1
regulates
- RNA polymerase II
- DNA promoter
- DNA endogenous promoter
- TBP
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Med17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- somatic stem cell maintenance
- positive regulation of transcription from RNA polymerase II promoter
- transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- core mediator complex
- ubiquitin ligase complex
- mediator complex
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription cofactor activity
- transcription coactivator activity
- ligand-dependent nuclear receptor transcription coactivator activity
- vitamin D receptor binding
- thyroid hormone receptor binding