Med12 Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin binding activity; and transcription coactivator activity. Acts upstream of or within several processes, including chordate embryonic development; embryonic brain development; and glial cell development. Part of mediator complex. Is expressed in brain; tibialis anterior; and tongue. Human ortholog(s) of this gene implicated in FG syndrome; leiomyosarcoma; major depressive disorder; phobic disorder; and syndromic X-linked intellectual disorder Lujan-Fryns-type. Orthologous to human MED12 (mediator complex subunit 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Med12 |
| Official Name | mediator complex subunit 12 [Source:MGI Symbol;Acc:MGI:1926212] |
| Ensembl ID | ENSMUSG00000079487 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 12 |
| Synonyms | ARC240, CAGH45, FGS1, HDKR, HOPA, Kto, LOC683401, MED12S, mediator complex subunit 12, Mopa, OHDOX, OKS, OPA-1, OPA containing, OPA-containing protein 1, TNRC11, TRAP230 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Med12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- nucleic acid binding
- ubiquitin protein ligase activity
- transcription cofactor
- transcription factor binding
- chromatin binding
- protein binding
- thyroid hormone receptor binding
- sequence-specific DNA binding
- Eukaryotic Mediator 12 catenin-binding domain
- Eukaryotic Mediator 12 subunit domain
- double-stranded DNA binding
- MED12 activation helix
- Transcription mediator complex subunit Med12
Pathways
Biological processes and signaling networks where the Med12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- cancer
- benign neoplasia
- hereditary disorder
- fibroepithelial breast tumor
- neoplasia
- familial thoracic aortic aneurysms and dissections
- uterine leiomyoma
- leiomyomatosis
- MED12-related intellectual disability syndrome
role in cell
- apoptosis
- phosphorylation in
- expression in
- survival
- proliferation
- cisplatin resistance
- berzosertib resistance
- differentiation
- berzosertib sensitivity
- olaparib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Med12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte development
- axis elongation involved in somitogenesis
- Schwann cell development
- positive regulation of transcription initiation from RNA polymerase II promoter
- endoderm development
- embryonic neurocranium morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- spinal cord development
- heart development
- neural tube closure
- positive regulation of transcription, DNA-dependent
- somatic stem cell maintenance
- Wnt receptor signaling pathway, planar cell polarity pathway
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- mediator complex
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription cofactor activity
- transcription coactivator activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- ligand-dependent nuclear receptor transcription coactivator activity
- vitamin D receptor binding
- transcription factor binding
- beta-catenin binding
- chromatin binding
- thyroid hormone receptor binding