Fpr2 Gene Summary [Mouse]
Enables N-formyl peptide receptor activity and amyloid-beta binding activity. Involved in cellular response to amyloid-beta; positive chemotaxis; and positive regulation of superoxide anion generation. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human FPR2 (formyl peptide receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fpr2 |
| Official Name | formyl peptide receptor 2 [Source:MGI Symbol;Acc:MGI:1278319] |
| Ensembl ID | ENSMUSG00000052270 |
| Bio databases IDs | |
| Aliases | formyl peptide receptor 2 |
| Synonyms | ALX, ALXR, E330010I07Rik, FMLP-R-II, FMLPX, formyl peptide receptor 2, FPR2A, FPRH1, FPRH2, FPRL1, Fpr-rs2, HM63, LXA4-R |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fpr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- signaling receptor activity
- scavenger receptor binding
- N-formyl peptide receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- receptor binding
- beta-amyloid binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Fpr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- neoplasia
- edema
- diabetic peripheral neuropathy
- focal cortical dysplasia of Taylor type IIB
- Alzheimer disease
- endometriosis
- systemic sclerosis
- colitis
- experimentally induced airway hyperresponsiveness
role in cell
- chemotaxis
- phosphorylation in
- apoptosis
- migration
- upregulation in
- quantity
- expression in
- production in
- adhesion
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- membrane fraction
- Cytoplasm
- cell surface
- cellular membrane
- secretory granule membrane
- tertiary granule membrane
- specific granule membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fpr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway
- positive regulation of monocyte chemotaxis
- positive chemotaxis
- negative regulation of inflammatory response
- cell adhesion
- cell surface receptor signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
- complement receptor mediated signaling pathway
- defense response to bacterium
- elevation of cytosolic calcium ion concentration
- chemotaxis
- inflammatory response
- positive regulation of innate immune response
- immune response-regulating cell surface receptor signaling pathway
- positive regulation of ERK1 and ERK2 cascade
- calcium-mediated signaling
- positive regulation of phagocytosis
- positive regulation of superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- tertiary granule membrane
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- complement receptor activity
- G-protein coupled receptor activity
- protein binding
- signaling receptor activity
- N-formyl peptide receptor activity
- scavenger receptor binding
- beta-amyloid binding