Cert1 Gene Summary [Mouse]
Enables kinase activity. Involved in ER to Golgi ceramide transport. Acts upstream of or within several processes, including ceramide metabolic process; in utero embryonic development; and lipid homeostasis. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; eye; nervous system; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 34. Orthologous to human CERT1 (ceramide transporter 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cert1 |
| Official Name | ceramide transporter 1 [Source:MGI Symbol;Acc:MGI:1915268] |
| Ensembl ID | ENSMUSG00000021669 |
| Bio databases IDs | |
| Aliases | ceramide transporter 1 |
| Synonyms | 2810404O15Rik, 9230101K08Rik, ceramide transporter 1, CERT, CERTL, COL4A3BP, GPBP, GPBP-1, GPBP-1,3, MRD34, NEDHSF, STARD11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cert1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- SRPBCC domain
- lipid transporter
- protein kinase
- sphingolipid binding
- binding protein
- PH domain
- sphingolipid transporter
- protein binding
- Pleckstrin homology-like domain
- identical protein binding
- phosphatidylinositol binding
Pathways
Biological processes and signaling networks where the Cert1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- Alzheimer disease
- hyperlipidemia
- lung adenocarcinoma
- lung adenocarcinoma formation
- cardiovascular disorder
- hypercholesterolemia
- hereditary disorder
- metabolic disorder
- primary genetic hyperlipidemia
phenotypes
- increased grip strength
- preweaning lethality incomplete penetrance
- abnormal cardiac jelly morphology
- abnormal cardiac outflow tract development
- abnormal cardiovascular system physiology
- abnormal cell physiology
- abnormal cervical rib
- abnormal endoplasmic reticulum morphology
- abnormal forebrain morphology
- abnormal heart morphology
- abnormal lipid homeostasis
- abnormal mitochondrial physiology
- abnormal mitochondrion morphology
- abnormal muscle development
- abnormal nasal cavity morphology
- abnormal optic cup morphology
- abnormal pectinate muscle morphology
- abnormal placenta morphology
- abnormal placental labyrinth vasculature morphology
- abnormal semicircular canal morphology
- abnormal trophoblast layer morphology
- abnormal umbilical vein topology
- abnormal vertebral arch morphology
- abnormal vertebral artery topology
- absent tibia
- aphakia
- decreased cell proliferation
- decreased cervical vertebrae number
- decreased embryo size
- decreased ventricle muscle contractility
- double outlet right ventricle
- embryonic lethality during organogenesis complete penetrance
- fetal growth retardation
- fusion of vertebral arches
- fusion of vertebral bodies
- heterochrony
- increased heart ventricle size
- muscular ventricular septal defect
- perimembraneous ventricular septal defect
- persistent right dorsal aorta
- persistent trigeminal artery
- persistent truncus arteriosis
- placenta hemorrhage
- placenta necrosis
- small placenta
- thin ventricular wall
role in cell
- activation in
- apoptosis
- organization
- proliferation
- formation
- formation in
- chemotaxis
- degeneration
- morphogenesis
- internalization by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
- nucleoplasm
- multivesicular bodies
- basement membrane
- glomerular basement membrane
- endothelial basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cert1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- signal transduction
- lipid homeostasis
- cell morphogenesis
- ceramide metabolic process
- endoplasmic reticulum organization
- mitochondrion organization
- heart morphogenesis
- immune response
- in utero embryonic development
- muscle contraction
- ceramide transport
- ER to Golgi ceramide transport
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- mitochondrion
- cytosol
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ceramide binding
- protein binding
- kinase activity