Apcs Gene Summary [Mouse]
Predicted to enable several functions, including complement component C1q complex binding activity; identical protein binding activity; and virion binding activity. Predicted to be involved in several processes, including host-mediated suppression of symbiont invasion; negative regulation by host of viral glycoprotein metabolic process; and negative regulation of exo-alpha-sialidase activity. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in amyloidosis. Orthologous to human APCS (amyloid P component, serum). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apcs |
| Official Name | serum amyloid P-component [Source:MGI Symbol;Acc:MGI:98229] |
| Ensembl ID | ENSMUSG00000026542 |
| Bio databases IDs | |
| Aliases | serum amyloid P-component |
| Synonyms | amyloid P component, serum, HEL-S-92n, PTX2, SAP, Serum Amyloid P, Serum amyloid p-component |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Apcs often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- virion binding
- Concanavalin A-like lectin/glucanases superfamily
- binding protein
- LamG
- calcium ion binding
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Apcs gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- hepatocellular carcinoma
- complete testicular feminization syndrome
- epithelial cancer
- spontaneous lupus nephritis
- Marfan syndrome
- weight loss
- cold thyroid nodule
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
role in cell
- cell death
- adhesion
- quantity
- expression in
- apoptosis
- differentiation
- production in
- cellular infiltration by
- accumulation
- agglutination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Nucleus
- myofilaments
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Apcs gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of wound healing
- negative regulation of viral entry into host cell
- innate immune response
- chaperone-mediated protein complex assembly
- negative regulation of viral reproduction
- protein folding
- acute-phase response
- negative regulation of monocyte differentiation
- negative regulation of acute inflammatory response
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- virion binding
- identical protein binding
- protein binding
- calcium ion binding
- complement component C1q binding
- unfolded protein binding
- carbohydrate binding