Ftsj1 Gene Summary [Mouse]
Predicted to enable S-adenosyl-L-methionine binding activity; tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity; and tRNA 2'-O-methyltransferase activity. Predicted to be involved in cytoplasmic translation; neurogenesis; and wobble position ribose methylation. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in ovary; oviduct; and uterus. Used to study non-syndromic X-linked intellectual disability 9. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 9. Orthologous to human FTSJ1 (FtsJ RNA 2'-O-methyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ftsj1 |
| Official Name | FtsJ RNA methyltransferase homolog 1 (E. coli) [Source:MGI Symbol;Acc:MGI:1859648] |
| Ensembl ID | ENSMUSG00000031171 |
| Bio databases IDs | |
| Aliases | FtsJ RNA methyltransferase homolog 1 (E. coli) |
| Synonyms | CDLIV, FTSJ, Ftsjl, FtsJ RNA 2'-O-methyltransferase 1, JM23, MRX44, MRX9, RGD1561061, Sfc12, SPB1, TRMT7, XLID9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ftsj1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methyltransferase
- O-methyltransferase
- tRNA methyltransferase
- binding protein
- tRNA (guanine) methyltransferase
- RNA methyltransferase
- viral Cap-0 specific (nucleoside-2'-O-)-methyltransferase
- enzyme
- protein binding
- tRNA (cytosine)-methyltransferase
- AdoMet_MTases
- methyltransferase domain
Pathways
Biological processes and signaling networks where the Ftsj1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-small cell lung cancer
- X-linked mental retardation type 9
- hereditary disorder
- X-linked complex neurodevelopmental disorder
- mental retardation
regulated by
regulates
role in cell
- expression in
- apoptosis
- proliferation
- migration
- abnormal morphology
- long-term potentiation
- plasticity
- long term synaptic depression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ftsj1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA nucleoside ribose methylation
- cytoplasmic translation
- wobble position ribose methylation
- neurogenesis
- tRNA methylation
- tRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- tRNA methyltransferase activity
- tRNA (guanine) methyltransferase activity