Taf15 Gene Summary [Mouse]
Enables mRNA 3'-UTR binding activity. Acts upstream of or within RNA splicing. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; hemolymphoid system gland; pancreas epithelium; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in chondrosarcoma and extraskeletal myxoid chondrosarcoma. Orthologous to human TAF15 (TATA-box binding protein associated factor 15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Taf15 |
| Official Name | TATA-box binding protein associated factor 15 [Source:MGI Symbol;Acc:MGI:1917689] |
| Ensembl ID | ENSMUSG00000020680 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor 15 |
| Synonyms | 2610111C21Rik, LOC103694865, LOC688079, Npl3, RBP56, TAF2N, TAF68, TAFII68, TATA-box binding protein associated factor 15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Taf15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RGG domain
- RNA recognition motif (RRM) superfamily
- Ser-Tyr-Gln-Gly-rich transactivating domain
- low complexity domain
- RNA recognition motif
- protein binding
- glutamine serine tyrosine-rich domain
- G/S Y G/S triplet repeat
- RNA binding
- Zn-finger in Ran binding protein and others
- mRNA 3' UTR binding
- zinc finger domain
- RNA-binding domain
Pathways
Biological processes and signaling networks where the Taf15 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung cancer
- epithelial cancer
- liver cancer
- amyotrophic lateral sclerosis
- malignant neoplasm of lung
- hepatocellular carcinoma
- gastric cancer
- extraskeletal myxoid chondrosarcoma
- soft tissue sarcoma cancer
role in cell
- expression in
- invasion by
- phosphorylation in
- proliferation
- migration
- colony formation by
- sumoylation in
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Taf15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- positive regulation of transcription, DNA-dependent
- mRNA stabilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- transcription cofactor activity
- metal ion binding
- mRNA 3'-UTR binding