Alox15 Gene Summary [Mouse]
Enables arachidonate 12(S)-lipoxygenase activity and arachidonate 15-lipoxygenase activity. Involved in several processes, including fatty acid metabolic process; phosphatidylethanolamine biosynthetic process; and positive regulation of actin filament polymerization. Acts upstream of or within bone mineralization. Located in cytosol and plasma membrane. Is expressed in several structures, including alimentary system; liver; nose; peritoneal fluid; and respiratory system. Orthologous to human ALOX15 (arachidonate 15-lipoxygenase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alox15 |
| Official Name | arachidonate 15-lipoxygenase [Source:MGI Symbol;Acc:MGI:87997] |
| Ensembl ID | ENSMUSG00000018924 |
| Bio databases IDs | |
| Aliases | arachidonate 15-lipoxygenase |
| Synonyms | 12/15 LO, 12/15-LOX, 12-Lipoxygenase, 12-LO, 12-LOX, 15-Lipoxygenase, 15-LOX, 15-LOX-1, Alox12, Alox12l, arachidonate 15-lipoxygenase, Arachidonate 5-lipoxygenase, L-12LO, L12lox, Leukocyte-type 12-lo |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Alox15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipoxygenase
- arachidonate 12-lipoxygenase
- phosphatidylinositol-4,5-bisphosphate binding
- intramolecular transferase activity, transferring hydroxy groups
- PLAT
- arachidonate 15-lipoxygenase
- hepoxilin-epoxide hydrolase
- iron ion binding
- enzyme
- Lipoxygenase homology 2 (beta barrel) domain
- potassium channel inhibitor
Pathways
Biological processes and signaling networks where the Alox15 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- insulin-dependent diabetes mellitus
- atherosclerosis
- diabetic nephropathy
- abdominal aortic aneurysm
- dextran sodium sulfate-induced colitis
- mechanical hypersensitivity
- renal fibrosis
- anemia
- TNBS-induced colitis
role in cell
- expression in
- migration
- hypertrophy
- phosphorylation in
- apoptosis
- adhesion
- generation in
- volume
- formation in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- cellular membrane
- Plasma Membrane
- endosomes
- Mitochondria
- lipid droplets
- cytosol
- cytoplasmic face of plasma membrane
- cytoplasmic droplets
- growth cone
- sarcolemma