Ktn1 Gene Summary [Mouse]
Predicted to enable kinesin binding activity. Predicted to be involved in protein transport. Predicted to act upstream of or within microtubule-based movement. Located in endoplasmic reticulum. Is expressed in several structures, including genitourinary system; gut; heart; hemolymphoid system gland; and lung. Orthologous to human KTN1 (kinectin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ktn1 |
| Official Name | kinectin 1 [Source:MGI Symbol;Acc:MGI:109153] |
| Ensembl ID | ENSMUSG00000021843 |
| Bio databases IDs | |
| Aliases | kinectin 1 |
| Synonyms | CG1, KINECTIN, kinectin 1, KNT, Ktn, MU-RMS-40.19 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ktn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- Crescentin protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Synaptonemal complex protein 1 (SCP-1)
- rad50
- helix-rich Mycoplasma protein
- protein binding
- kinesin binding
- FG repeat
- Ribosome receptor lysine/proline rich region
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- RIM-binding protein of the cytomatrix active zone
- Coiled-coil domain-containing protein 158
- Rho-binding domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Ktn1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ischemic stroke
- proliferative diabetic retinopathy
- peripheral arterial disease
role in cell
- morphology
- movement by
- movement
- disruption
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane vesicles
- polyribosome fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- Cytoplasm
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- mitochondrial nucleoids
- growth cone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ktn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
- microtubule-based movement
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- cadherin binding
- kinesin binding