Atg4b Gene Summary [Mouse]
Enables cysteine-type peptidase activity. Involved in several processes, including autophagosome assembly; otolith mineralization completed early in development; and protein delipidation. Located in cytoplasm. Is expressed in central nervous system; genitourinary system; gut; lymph node; and sensory organ. Orthologous to human ATG4B (autophagy related 4B cysteine peptidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atg4b |
| Official Name | autophagy related 4B, cysteine peptidase [Source:MGI Symbol;Acc:MGI:1913865] |
| Ensembl ID | ENSMUSG00000026280 |
| Bio databases IDs | |
| Aliases | autophagy related 4B, cysteine peptidase |
| Synonyms | 2510009N07Rik, APG4B, Atg4, Atg4bl, AUTL1, Autophagin-1, autophagy related 4B cysteine peptidase, autophagy related 4B, cysteine peptidase, AW048066, HsAPG4B, KIAA0943, MmAPG4B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atg4b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- APG8-specific protease
- endopeptidase
- cysteine-type peptidase
- cysteine endopeptidase
- peptidase
- Peptidase family C54
- ATG4, F-type LIR motif
- active site
- protein binding
Pathways
Biological processes and signaling networks where the Atg4b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- gastric carcinoma
- gastric epithelial cancer
- organismal death
- nonalcoholic steatohepatitis
- hearing loss
- early onset glaucoma
- arteriosclerosis
role in cell
- survival
- accumulation in
- cell viability
- migration
- cell death
- replication in
- formation
- formation in
- accumulation
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atg4b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization to pre-autophagosomal structure
- otolith mineralization completed early in development
- protein transport
- C-terminal protein lipidation
- macromitophagy
- protein delipidation
- autophagic vacuole assembly
- piecemeal microautophagy of nucleus
- autophagy
- proteolysis
- protein processing
- aggrephagy
- macroautophagy
- microautophagy
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytoplasmic vesicle
- cytosol
- endoplasmic reticulum
- autophagic vacuole membrane
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- protein binding
- endopeptidase activity
- cysteine-type endopeptidase activity
- APG8-specific protease activity
- cysteine-type peptidase activity