Arhgef3 Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of Rho protein signal transduction. Predicted to be located in cytoplasm. Is expressed in several structures, including bone marrow; enteric nervous system; forelimb bud; liver; and testis. Orthologous to human ARHGEF3 (Rho guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgef3 |
| Official Name | Rho guanine nucleotide exchange factor (GEF) 3 [Source:MGI Symbol;Acc:MGI:1918954] |
| Ensembl ID | ENSMUSG00000021895 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor (GEF) 3 |
| Synonyms | 1200004I24Rik, 9830169H03RIK, GEF3, RHO GEF, Rho guanine nucleotide exchange factor 3, STA3, XPLN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgef3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- guanyl-nucleotide exchange factor
- PH domain
- protein binding
- Pleckstrin homology-like domain
- Dbl homology domain
- RhoGEF domain
Pathways
Biological processes and signaling networks where the Arhgef3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- Duchenne muscular dystrophy
- coronary artery disease
- idiopathic dilated cardiomyopathy
- glaucoma
- open-angle glaucoma
- neoplasia
- prostate cancer
- hemorrhagic disease
role in cell
- expression in
- proliferation
- apoptosis
- phosphorylation in
- differentiation
- transformation
- assembly
- binding in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgef3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rho protein signal transduction
- regulation of small GTPase mediated signal transduction
- Rho protein signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity