Akap13 Gene Summary [Mouse]
Predicted to enable several functions, including MAP-kinase scaffold activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Involved in bone development; cardiac muscle cell differentiation; and regulation of sarcomere organization. Acts upstream of or within regulation of nuclear receptor-mediated glucocorticoid signaling pathway. Colocalizes with actin filament. Is expressed in 1st branchial arch; cardiac muscle tissue; future forebrain; heart; and limb. Orthologous to human AKAP13 (A-kinase anchoring protein 13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akap13 |
| Official Name | A kinase (PRKA) anchor protein 13 [Source:MGI Symbol;Acc:MGI:2676556] |
| Ensembl ID | ENSMUSG00000066406 |
| Bio databases IDs | |
| Aliases | A kinase (PRKA) anchor protein 13 |
| Synonyms | 1700026G02RIK, 5730522G15RIK, 5830460E08RIK, AKAP-Lbc, A-kinase anchoring protein 13, A kinase anchor protein 13, ARHGEF13, BRX, c-lbc, HA-3, HT31, LBC, LOC233400, LOC293024, p47, P47 LBC oncogene, PRKA13, PROTO-LB, PROTO-LBC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Akap13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Flagellar FliJ protein
- protein kinase A binding
- alpha helix
- enzyme binding
- R2 binding domain
- protein binding
- Pleckstrin homology-like domain
- RhoGEF domain
- phosphorylation site
- MAP-kinase scaffold protein
- RhoGEF
- protein kinase C conserved region 1 (C1 domain) superfamily
- guanyl-nucleotide exchange factor
- PH domain
- guanine nucleotide exchange factor domain
- Dbl homology domain
Pathways
Biological processes and signaling networks where the Akap13 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- coronary artery disease
- breast cancer
- nasopharyngeal cancer
- nasopharyngeal carcinoma
- frozen shoulder
- gout
- sarcomatoid nasopharyngeal carcinoma
- sarcomatoid cancer
role in cell
- expression in
- formation
- binding in
- differentiation
- phosphorylation in
- proliferation
- size
- formation in
- growth
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cortical actin cytoskeleton
- perinuclear region
- cellular membrane
- actin cytoskeleton
- cell cortex
- Nucleus
- Plasma Membrane
- actin filaments
- sarcomere
- cytosol
- sarcolemma
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Akap13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of sarcomere organization
- heart development
- regulation of Rho protein signal transduction
- MAPK cascade
- positive regulation of Rho protein signal transduction
- G-protein coupled receptor signaling pathway
- regulation of small GTPase mediated signal transduction
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- adrenergic receptor signaling pathway
- cardiac muscle cell differentiation
- bone development
Cellular Component
Where in the cell the gene product is active
- nucleus
- cell cortex
- membrane
- actin cytoskeleton
- cytosol
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- guanyl-nucleotide exchange factor activity
- small GTPase binding
- MAP-kinase scaffold activity
- protein kinase A binding
- binding, bridging