Tdrd3 Gene Summary [Mouse]
Predicted to enable chromatin binding activity; methylated histone binding activity; and transcription coactivator activity. Predicted to be involved in DNA topological change. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of DNA topoisomerase III-beta-TDRD3 complex and exon-exon junction complex. Predicted to be active in nucleus. Orthologous to human TDRD3 (tudor domain containing 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tdrd3 |
| Official Name | tudor domain containing 3 [Source:MGI Symbol;Acc:MGI:2444023] |
| Ensembl ID | ENSMUSG00000022019 |
| Bio databases IDs | |
| Aliases | tudor domain containing 3 |
| Synonyms | 4732418C03Rik, 6720468N18, tudor domain containing 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tdrd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- RecQ mediated genome instability protein
- histone binding
- transcription regulator
- transcription co-activator
- protein binding activity, bridging
- chromatin binding
- protein binding
- Tudor domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- metastasis
- organismal death
- colorectal cancer
- advanced cancer
role in cell
- expression in
- proliferation
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Golgi Apparatus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tdrd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- exon-exon junction complex
- cytosol
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- transcription coactivator activity
- methylated histone residue binding
- chromatin binding