Psmb9 Gene Summary [Mouse]
Predicted to enable endopeptidase activity and proteasome binding activity. Acts upstream of or within antigen processing and presentation and response to bacterium. Part of proteasome core complex and spermatoproteasome complex. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); lymphoma; and renal cell carcinoma. Orthologous to human PSMB9 (proteasome 20S subunit beta 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmb9 |
| Official Name | proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) [Source:MGI Symbol;Acc:MGI:1346526] |
| Ensembl ID | ENSMUSG00000096727 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) |
| Synonyms | Beta 1i, beta 1I IMMUNOPROTEASOME subunit, large multifunctional protease 2, LMP2, PRAAS3, PRAAS6, proteasome 20S subunit beta 9, proteasome 20S subunit β 9, proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2), proteasome (prosome, macropain) subunit, β type 9 (large multifunctional peptidase 2), proteasome subunit X, Proteasome subunit, β type, 9, Psamb9, PSMB6i, RING12, β 1i, β 1I IMMUNOPROTEASOME subunit |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmb9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- proteasome endopeptidase complex
- binding protein
- proteasome, beta subunit, bacterial type
- peptidase
- protein binding
- Proteasome subunit
Pathways
Biological processes and signaling networks where the Psmb9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- abdominal cancer
- epithelial cancer
- cancer
- epithelial neoplasia
- neoplasia
- COVID-19
- non-insulin-dependent diabetes mellitus
- refractory multiple myeloma
- plasma cell myeloma
- relapsed multiple myeloma
role in cell
- quantity
- expression in
- activation
- number
- abnormal morphology
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- clastosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmb9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of cysteine-type endopeptidase activity
- immune system process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- proteasome core complex
- cytosol
- proteasome complex
- proteasome core complex, beta-subunit complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- endopeptidase activity
- threonine-type endopeptidase activity