Ropn1l Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Acts upstream of or within flagellated sperm motility; regulation of protein phosphorylation; and sperm capacitation. Located in motile cilium. Part of radial spoke. Is expressed in several structures, including heart; liver; lung; reproductive system; and spleen. Orthologous to human ROPN1L (rhophilin associated tail protein 1 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ropn1l |
| Official Name | ropporin 1-like [Source:MGI Symbol;Acc:MGI:2182357] |
| Ensembl ID | ENSMUSG00000022236 |
| Bio databases IDs | |
| Aliases | ropporin 1-like |
| Synonyms | Akapasp, ASP, LINC01513, LOC101929379, LOC683424, LOC728124, rhophilin associated tail protein 1-like, ropporin 1-like, RSPH11, TCONS 00009352 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ropn1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein binding
- DD_R_PKA_DPY30-like
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- coronary artery disease
- breast carcinoma
- lung squamous cell carcinoma
- squamous cell lung cancer
- cryptorchidism
regulated by
- HCAR2
- diphtheria toxin
- propylthiouracil
- dimethyl n-oxalyl-glycine
role in cell
- motility
- movement
- capacitation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- intracellular membrane-bounded organelle
- cilia
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ropn1l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm motility
- sperm capacitation
- regulation of protein phosphorylation
- epithelial cilium movement
Cellular Component
Where in the cell the gene product is active
- motile cilium
- radial spoke
- cytoplasm
- cilium
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding