Spa17 Gene Summary [Mouse]
Predicted to enable calmodulin binding activity. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Located in several cellular components, including external side of plasma membrane; neuron projection; and sperm flagellum. Is expressed in several structures, including brain; gonad; heart; hemolymphoid system gland; and lung. Orthologous to human SPA17 (sperm autoantigenic protein 17). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spa17 |
| Official Name | sperm autoantigenic protein 17 [Source:MGI Symbol;Acc:MGI:1333778] |
| Ensembl ID | ENSMUSG00000001948 |
| Bio databases IDs | |
| Aliases | sperm autoantigenic protein 17 |
| Synonyms | CT22, SP17, SP17-1, sperm autoantigenic protein 17 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spa17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calmodulin-binding motif
- protein binding
- DD_R_PKA_DPY30-like
- IQ calmodulin-binding motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- motile cilia
- Cytoplasm
- cilia
- cell surface
- cellular membrane
- plasma membrane extracellular face
- sperm fibrous sheath
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spa17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
- spermatogenesis
- epithelial cilium movement
- single fertilization
Cellular Component
Where in the cell the gene product is active
- motile cilium
- cytoplasm
- cilium
- external side of plasma membrane
- sperm principal piece
- flagellar fibrous sheath
- extracellular region
- neuron projection
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding