Cdh10 Gene Summary [Mouse]

This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is expressed in the blood-brain barrier and retinal endothelia suggesting a role in the development and maintenance of brain barrier. Alternative splicing results in multiple transcript variants. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 15. [provided by RefSeq, Oct 2015]

Details

Type
Protein Coding
Official Symbol
Cdh10
Official Name
cadherin 10 [Source:MGI Symbol;Acc:MGI:107436]
Ensembl ID
ENSMUSG00000022321
Bio databases IDs NCBI: 320873 Ensembl: ENSMUSG00000022321
Aliases cadherin 10
Synonyms A830016G23RIK, C030003B10RIK, C030011H18RIK, cadherin 10, T2-cadherin
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdh10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Cadherin, Y-type LIR-motif
  • Cadherin repeat-like domain

Pathways

Biological processes and signaling networks where the Cdh10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • idiopathic scoliosis
  • preeclampsia
  • myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
regulated by
regulates
role in cell
  • size

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • glutaminergic synapse
  • presynaptic regions
  • postsynaptic region
  • cellular membrane
  • presynaptic membrane
  • synaptic membrane
  • synapse
  • postsynaptic density
  • inhibitory synapse
  • excitatory synapses

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdh10 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • calcium-dependent cell-cell adhesion
  • cell-cell junction assembly
  • adherens junction organization
  • multicellular organismal development
  • cell-cell adhesion mediated by cadherin
  • cell morphogenesis
  • homophilic cell adhesion
  • cell migration

Cellular Component

Where in the cell the gene product is active
  • adherens junction
  • catenin complex
  • presynaptic active zone membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • calcium ion binding
  • cadherin binding
  • beta-catenin binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.