Ctnna3 Gene Summary [Mouse]
Predicted to enable actin filament binding activity and beta-catenin binding activity. Involved in cell-cell adhesion. Located in adherens junction; fascia adherens; and lamellipodium. Is expressed in cardiac muscle tissue and skin of male preputial swelling. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular dysplasia 13. Orthologous to human CTNNA3 (catenin alpha 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctnna3 |
| Official Name | catenin (cadherin associated protein), alpha 3 [Source:MGI Symbol;Acc:MGI:2661445] |
| Ensembl ID | ENSMUSG00000060843 |
| Bio databases IDs | |
| Aliases | catenin (cadherin associated protein), alpha 3 |
| Synonyms | 4930429L08RIK, 4933408A16, AABR07044900.1, Alpha T-catenin, ARVD13, catenin alpha 3, catenin α 3, Catna3, LOC100362857, RGD1559455, RGD1562230, VR22, α T-catenin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ctnna3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Vinculin family
- beta-catenin binding
- cadherin binding
- protein binding
Pathways
Biological processes and signaling networks where the Ctnna3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- schizophrenia
- migraines
- Alzheimer disease
- edema
- psoriatic arthritis
- major depression
- hypertension
- depressive disorder
- toluene diisocyanate-induced asthma
role in cell
- differentiation
- abnormal morphology
- compaction
- cell-cell adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- paranodes
- intercalated disks
- anchoring junction
- cell-cell adherens junctions
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ctnna3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of heart rate by cardiac conduction
- cell migration
- bundle of His cell-Purkinje myocyte adhesion involved in cell communication
Cellular Component
Where in the cell the gene product is active
- adherens junction
- cytoskeleton
- cytoplasm
- fascia adherens
- desmosome
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- cadherin binding
- beta-catenin binding