Cops6 Gene Summary [Mouse]
Predicted to enable metallopeptidase activity. Predicted to be involved in protein deneddylation. Part of COP9 signalosome. Is expressed in several structures, including brown fat; central nervous system; male reproductive system; sensory organ; and urinary system. Orthologous to human COPS6 (COP9 signalosome subunit 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cops6 |
| Official Name | COP9 signalosome subunit 6 [Source:MGI Symbol;Acc:MGI:1349439] |
| Ensembl ID | ENSMUSG00000019494 |
| Bio databases IDs | |
| Aliases | COP9 signalosome subunit 6 |
| Synonyms | COP9 signalosome subunit 6, CSN6, MOV-34, MOV34-34KD, Sgn3, VIP/MOV34 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cops6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mpr1p, Pad1p N-terminal (MPN) domains
- protein binding
- Maintenance of mitochondrial structure and function
Pathways
Biological processes and signaling networks where the Cops6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- neoplastic cell transformation
- clear-cell ovarian carcinoma
- clear cell ovarian cancer
role in cell
- migration
- expression in
- activation in
- growth
- degradation in
- proliferation
- tumorigenicity
- invasion by
- double-stranded DNA break repair in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cops6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deneddylation
- protein neddylation
- regulation of protein neddylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- signalosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- peptidase activity