Washc5 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Involved in meiotic spindle assembly; oocyte maturation; and polar body extrusion after meiotic divisions. Acts upstream of or within several processes, including lysosome organization; regulation of actin nucleation; and regulation of vesicle size. Located in endosome. Part of WASH complex. Is expressed in foregut; male reproductive system; nervous system; sensory organ; and vibrissa. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome 1 and hereditary spastic paraplegia 8. Orthologous to human WASHC5 (WASH complex subunit 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Washc5 |
| Official Name | WASH complex subunit 5 [Source:MGI Symbol;Acc:MGI:2146110] |
| Ensembl ID | ENSMUSG00000022350 |
| Bio databases IDs | |
| Aliases | WASH complex subunit 5 |
| Synonyms | E430025E21Rik, KIAA0196, LOC300314, RGD1564420, RTSC, RTSC1, SPG8, STRUMPELLIN, WASH complex subunit 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Washc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Hereditary spastic paraplegia protein strumpellin
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Ritscher-Schinzel syndrome type 1
- amyotrophic lateral sclerosis
- hereditary spastic paraplegia autosomal dominant 8
- hereditary disorder
- breast carcinoma
- hereditary spastic paraplegia
regulated by
- Influenza A virus (A/Japan/305/57(H2N2))
- NUPR1
regulates
- cholesterol
- actin
- protein-protein complex
- ATP7A
- VAMP7
role in cell
- organization
- development
- nucleation
- phagocytosis by
- exocytosis by
- maturation
- assembly
- regulation in
- fission
- transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endosomes
- endosomal compartment
- nucleoplasm
- early endosomes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Washc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- polar body extrusion after meiotic divisions
- lysosome organization
- endosome organization
- actin filament polymerization
- protein transport
- regulation of actin nucleation
- protein complex localization
- oocyte maturation
- endosomal transport
- positive regulation of neuron projection development
- spindle assembly involved in meiosis
- regulation of Arp2/3 complex-mediated actin nucleation
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- early endosome
- endosome
- cytosol
- endoplasmic reticulum
- WASH complex
- neuronal cell body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding