Sla Gene Summary [Mouse]
Predicted to enable epidermal growth factor receptor binding activity and phosphotyrosine residue binding activity. Predicted to be involved in regulation of MAPK cascade and signal transduction. Predicted to be located in endosome. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm; nucleoplasm; and plasma membrane. Is expressed in several structures, including alimentary system; brain; eye; hemolymphoid system; and musculoskeletal system. Orthologous to human SLA (Src like adaptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sla |
| Official Name | src-like adaptor [Source:MGI Symbol;Acc:MGI:104295] |
| Ensembl ID | ENSMUSG00000022372 |
| Bio databases IDs | |
| Aliases | src-like adaptor |
| Synonyms | SLA1, SLAP, Slap-1, Src like adaptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sla often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Src homology 2 (SH2) domain
- protein binding
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral arterial disease
- androgenic alopecia
- multiple sclerosis
- latent tuberculosis
- Waldenström macroglobulinemia
role in cell
- activation in
- function
- quantity
- phosphorylation in
- formation
- tyrosine phosphorylation in
- binding in
- S phase
- number
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- perinuclear region
- endosomes
- vesicles
- cytosol
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sla gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAPK cascade
- signal transduction
Cellular Component
Where in the cell the gene product is active
- endosome
- cytoplasm
- cytosol
- signalosome
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- protein binding
- epidermal growth factor receptor binding