Ptk6 Gene Summary [Mouse]
Predicted to enable identical protein binding activity; non-membrane spanning protein tyrosine kinase activity; and signaling receptor binding activity. Involved in intestinal epithelial cell differentiation and negative regulation of growth. Located in nucleus. Is expressed in several structures, including gut; liver; and skin. Orthologous to human PTK6 (protein tyrosine kinase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptk6 |
| Official Name | PTK6 protein tyrosine kinase 6 [Source:MGI Symbol;Acc:MGI:99683] |
| Ensembl ID | ENSMUSG00000038751 |
| Bio databases IDs | |
| Aliases | PTK6 protein tyrosine kinase 6 |
| Synonyms | Breast tumour kinase, BRK, protein tyrosine kinase 6, PTK6 protein tyrosine kinase 6, Sik, tks, Tksk |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptk6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- non-membrane spanning protein tyrosine kinase
- linker domain
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- identical protein binding
- Src Homology 3 domain superfamily
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Src homology 2 (SH2) domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Ptk6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- progressive medullary thyroid cancer
- thyroid oncocytic carcinoma
- follicular thyroid carcinoma
- medullary thyroid carcinoma
- lung cancer
- tumorigenesis
- medullary thyroid cancer
- non-small cell lung cancer
- cutaneous melanoma
role in cell
- phosphorylation in
- proliferation
- expression in
- invasion by
- degradation in
- migration
- downregulation in
- activation in
- apoptosis
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear bodies
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptk6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of growth
- tyrosine phosphorylation of STAT protein
- intestinal epithelial cell differentiation
- negative regulation of protein tyrosine kinase activity
- positive regulation of epidermal growth factor receptor signaling pathway
- transmembrane receptor protein tyrosine kinase signaling pathway
- protein autophosphorylation
- positive regulation of cell cycle
- positive regulation of DNA replication
- positive regulation of tyrosine phosphorylation of STAT protein
- protein phosphorylation
- cellular response to retinoic acid
- innate immune response
- cell differentiation
- positive regulation of neuron projection development
- ERBB2 signaling pathway
- cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- ruffle
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- identical protein binding
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- receptor binding