Osbpl3 Gene Summary [Mouse]
Predicted to enable cholesterol binding activity. Predicted to be involved in lipid transport. Predicted to be located in endoplasmic reticulum membrane and filopodium tip. Predicted to be active in several cellular components, including cytosol; nuclear membrane; and perinuclear endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; immune system; olfactory epithelium; and respiratory system. Orthologous to human OSBPL3 (oxysterol binding protein like 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Osbpl3 |
| Official Name | oxysterol binding protein-like 3 [Source:MGI Symbol;Acc:MGI:1918970] |
| Ensembl ID | ENSMUSG00000029822 |
| Bio databases IDs | |
| Aliases | oxysterol binding protein-like 3 |
| Synonyms | 1200014M06Rik, 6720421I08Rik, A530055M08, ORP-3, OSBP3, oxysterol binding protein-like 3, RGD1564287 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Osbpl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- cholesterol binding
- PH domain
- protein binding
- Pleckstrin homology-like domain
- Oxysterol-binding protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- gastric adenocarcinoma
- coronary artery disease
- colorectal cancer
- cervical cancer
- liver cancer
- epithelial cancer
- bladder cancer
- early childhood caries
- lung squamous cell carcinoma
regulates
- bile acid
role in cell
- migration
- invasion by
- aneuploidization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- centrosome
- Endoplasmic Reticulum
- cytosol
- reticular perinuclear compartment
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Osbpl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- bile acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
- perinuclear endoplasmic reticulum
- membrane
- cytosol
- filopodium tip
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cholesterol binding