Rab3ip Gene Summary [Mouse]
Enables identical protein binding activity and small GTPase binding activity. Predicted to be involved in several processes, including protein localization to motile cilium; protein targeting to membrane; and regulation of plasma membrane bounded cell projection assembly. Predicted to be located in several cellular components, including centrosome; perinuclear region of cytoplasm; and proximal dendrite. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human RAB3IP (RAB3A interacting protein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab3ip |
| Official Name | RAB3A interacting protein [Source:MGI Symbol;Acc:MGI:105933] |
| Ensembl ID | ENSMUSG00000064181 |
| Bio databases IDs | |
| Aliases | RAB3A interacting protein |
| Synonyms | B230311A06, FLJ22548, GTPAT12, RAB3A interacting protein, RABIN3, RABIN8, Rn8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab3ip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab11BD_RAB3IP_like
- DivIVA protein
- Ezrin/radixin/moesin, alpha-helical domain
- prefoldin
- guanyl-nucleotide exchange factor
- enzyme binding
- protein binding
- TATA element modulatory factor 1 TATA binding
- identical protein binding
- GDP/GTP exchange factor Sec2p
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- small cell lung cancer
role in cell
- assembly
- ciliogenesis in
- autoinhibition in
- polarization
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- basal bodies
- centrosome
- cytosol
- membrane ruffles
- nucleoplasm
- dendrite initial segments
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab3ip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- protein transport
- negative regulation of filopodium assembly
- positive regulation of flagellum assembly
- exocytosis
- protein targeting to membrane
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- Golgi to plasma membrane transport vesicle
- perinuclear region of cytoplasm
- cytosol
- trans-Golgi network membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase binding
- guanyl-nucleotide exchange factor activity