Naga Gene Summary [Mouse]
Predicted to enable alpha-N-acetylgalactosaminidase activity; alpha-galactosidase activity; and protein homodimerization activity. Predicted to be involved in several processes, including glycolipid catabolic process; glycoside catabolic process; and oligosaccharide metabolic process. Predicted to be located in lysosome and membrane. Predicted to be active in cytoplasm. Is expressed in nervous system and skeleton. Human ortholog(s) of this gene implicated in Kanzaki disease; Schindler disease type 1; angiokeratoma; and neuroaxonal dystrophy. Orthologous to human NAGA (alpha-N-acetylgalactosaminidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Naga |
| Official Name | N-acetyl galactosaminidase, alpha [Source:MGI Symbol;Acc:MGI:1261422] |
| Ensembl ID | ENSMUSG00000022453 |
| Bio databases IDs | |
| Aliases | N-acetyl galactosaminidase, alpha |
| Synonyms | alpha-N-acetylgalactosaminidase, D22S674, GALB, N-acetyl galactosaminidase, alpha, N-acetyl galactosaminidase, α, O-GLYCANASE, α-N-acetylgalactosaminidase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Naga often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha amylase catalytic domain family
- protein homodimerization
- alpha-N-acetylgalactosaminidase
- Alpha galactosidase C-terminal beta sandwich domain
- enzyme
- Alpha galactosidase A C-terminal beta sandwich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Kanzaki disease
- alpha-N-acetylgalactosaminidase deficiency type III
- Schindler disease
- alpha-N-acetylgalactosaminidase deficiency
- hereditary disorder
- NAGA-related disorder
role in cell
- adhesion
- activation in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Naga gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoside catabolic process
- carbohydrate catabolic process
- glycolipid catabolic process
- oligosaccharide metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- lysosome
Molecular Function
What the gene product does at the molecular level
- alpha-galactosidase activity
- protein homodimerization activity
- alpha-N-acetylgalactosaminidase activity