Metrnl Gene Summary [Mouse]
Enables hormone activity. Involved in several processes, including brown fat cell differentiation; positive regulation of brown fat cell differentiation; and response to muscle activity. Located in extracellular space. Is expressed in central nervous system; sensory organ; skeleton; and vibrissa. Orthologous to human METRNL (meteorin like, glial cell differentiation regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Metrnl |
| Official Name | meteorin, glial cell differentiation regulator-like [Source:MGI Symbol;Acc:MGI:2384806] |
| Ensembl ID | ENSMUSG00000039208 |
| Bio databases IDs | |
| Aliases | meteorin, glial cell differentiation regulator-like |
| Synonyms | 9430048M07Rik, LOC653506, meteorin, glial cell differentiation regulator-like, meteorin-like, glial cell differentiation regulator |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Metrnl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hormone
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- colonic polyp
- epileptic seizure
role in cell
- differentiation
- glycolysis in
- production in
- activation
- polarization
- polarization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Metrnl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cold
- brown fat cell differentiation
- response to muscle activity
- positive regulation of brown fat cell differentiation
- signal transduction
- negative regulation of inflammatory response
- energy homeostasis
- fat cell differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- hormone activity