Slc31a1 Gene Summary [Mouse]
Enables copper ion transmembrane transporter activity; silver ion transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in angiogenesis; transition metal ion transport; and xenobiotic transport. Acts upstream of or within establishment of localization in cell and intracellular copper ion homeostasis. Located in several cellular components, including basolateral plasma membrane; endosome; and intercalated disc. Is expressed in several structures, including adrenal gland; alimentary system; early embryo; genitourinary system; and nervous system. Orthologous to human SLC31A1 (solute carrier family 31 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc31a1 |
| Official Name | solute carrier family 31, member 1 [Source:MGI Symbol;Acc:MGI:1333843] |
| Ensembl ID | ENSMUSG00000066150 |
| Bio databases IDs | |
| Aliases | solute carrier family 31, member 1 |
| Synonyms | 4930445G01Rik, Copper transporter 1, COPT1, CTR1, LRRGT00200, NSCT, solute carrier family 31 member 1, solute carrier family 31, member 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc31a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- silver ion transporter
- copper ion binding
- copper ion transporter
- xenobiotic transporter
- ectodomain
- Ctr copper transporter family
- protein binding
- identical protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- urothelial bladder carcinoma
- transitional cell bladder cancer
- neurodegeneration and seizures due to copper transport defect
- estrogen receptor positive breast cancer
- HER2 negative hormone receptor negative breast cancer
- developmental disorder
- HER2-positive breast cancer
- infection by chimpanzee endogenous retrovirus 2
role in cell
- growth
- cell death
- phosphorylation in
- survival
- quantity
- organismal death
- response by
- colony formation by
- uptake by
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- Cytoplasm
- cell periphery
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- intercellular junctions
- apical cell surfaces
- basolateral cell surfaces
- apical membrane
- basolateral membrane
- lateral plasma membrane
- endosomal membrane
- recycling endosomes
- late endosomes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc31a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- copper ion transport
- cellular copper ion homeostasis
- angiogenesis
- xenobiotic transport
- establishment of localization in cell
- plasma membrane copper ion transport
- protein oligomerization
- copper ion import
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- late endosome membrane
- intercalated disc
- recycling endosome membrane
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- xenobiotic transporter activity
- identical protein binding
- protein binding
- copper ion binding
- copper ion transmembrane transporter activity
- silver ion transmembrane transporter activity