Pmm1 Gene Summary [Mouse]
Predicted to enable phosphomannomutase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in cytoplasm and neuronal cell body. Is expressed in axial skeleton; genitourinary system; integumental system; limb; and nervous system. Orthologous to human PMM1 (phosphomannomutase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Pmm1 |
| Official Name | phosphomannomutase 1 [Source:MGI Symbol;Acc:MGI:1353418] |
| Ensembl ID | ENSMUSG00000022474 |
| Bio databases IDs | |
| Aliases | phosphomannomutase 1 |
| Synonyms | Phosphomannomutase, phosphomannomutase 1, PMMH-22, Sec53 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pmm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HAD-superfamily hydrolase, subfamily IIB
- enzyme
- protein binding
- Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily
- phosphomannomutase
- Haloacid Dehalogenase-like Hydrolases
- haloacid dehalogenase-like hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- glucose-1,6-bisphosphate
- mannose
- GDP-D-mannose
disease
- schizophrenia
- global developmental delay, absent or hypoplastic corpus callosum and dysmorphic facies
- infection by HIV-1
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell cortex
- cytosol
- neurite branches
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pmm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- GDP-mannose biosynthetic process
- mannose metabolic process
- protein N-linked glycosylation
Cellular Component
Where in the cell the gene product is active
- cytosol
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- phosphomannomutase activity