Maf1 Gene Summary [Mouse]
Predicted to enable GABA receptor binding activity; RNA polymerase III cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase III core binding activity. Involved in negative regulation of transcription by RNA polymerase III. Located in nucleus. Is expressed in adrenal gland; liver; retina; and thymus. Orthologous to human MAF1 (MAF1 homolog, negative regulator of RNA polymerase III). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Maf1 |
| Official Name | MAF1 homolog, negative regulator of RNA polymerase III [Source:MGI Symbol;Acc:MGI:1916127] |
| Ensembl ID | ENSMUSG00000022553 |
| Bio databases IDs | |
| Aliases | MAF1 homolog, negative regulator of RNA polymerase III |
| Synonyms | 1110068E11Rik, MAF1 homolog, negative regulator of RNA polymerase III |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Maf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Maf1 regulator
- double-stranded DNA binding
- nucleic acid binding
- protein binding
- receptor binding
- ribosomal DNA (rDNA) binding protein
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- weight gain
- growth failure
- nonalcoholic fatty liver disease
role in cell
- number
- apoptosis
- size
- formation
- transcription in
- synthesis in
- formation in
- repression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- Plasma Membrane
- cytosol
- nucleoplasm
- synapse
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Maf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase III promoter
- negative regulation of transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase III type 1 promoter sequence-specific DNA binding
- protein binding
- RNA polymerase III type 3 promoter sequence-specific DNA binding
- RNA polymerase III core binding
- RNA polymerase III type 2 promoter sequence-specific DNA binding