Polr3c Gene Summary [Mouse]
Predicted to enable single-stranded DNA binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase III complex. Orthologous to human POLR3C (RNA polymerase III subunit C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Polr3c |
| Official Name | polymerase (RNA) III (DNA directed) polypeptide C [Source:MGI Symbol;Acc:MGI:1921664] |
| Ensembl ID | ENSMUSG00000028099 |
| Bio databases IDs | |
| Aliases | polymerase (RNA) III (DNA directed) polypeptide C |
| Synonyms | 4933407E01Rik, C82, LOC101060460, polymerase (RNA) III (DNA directed) polypeptide C, RNA polymerase III subunit C, RPC3, RPC62 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polr3c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA binding
- DNA-directed RNA polymerase
- enzyme
- protein binding
- RNA polymerase III subunit RPC82 helix-turn-helix domain
- RNA polymerase III subunit RPC82
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Polr3c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of innate immune response
- transcription, DNA-dependent
- innate immune response
- positive regulation of interferon-beta production
- defense response to virus
- regulation of transcription from RNA polymerase III promoter
Cellular Component
Where in the cell the gene product is active
- cytosol
- DNA-directed RNA polymerase III complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA-directed RNA polymerase activity
- protein binding
- single-stranded DNA binding