Armcx3 Gene Summary [Mouse]
Acts upstream of or within several processes, including axonal transport of mitochondrion; mitochondrion organization; and positive regulation of transcription by RNA polymerase II. Located in cytosol; mitochondrial outer membrane; and nucleus. Is expressed in several structures, including central nervous system; hindlimb bud; jaw bone; mesenchyme derived from neural crest; and testis mesenchyme. Orthologous to human ARMCX3 (armadillo repeat containing X-linked 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Armcx3 |
| Official Name | armadillo repeat containing, X-linked 3 [Source:MGI Symbol;Acc:MGI:1918953] |
| Ensembl ID | ENSMUSG00000049047 |
| Bio databases IDs | |
| Aliases | armadillo repeat containing, X-linked 3 |
| Synonyms | 1200004E24Rik, ALEX3, armadillo repeat containing X-linked 3, armadillo repeat containing, X-linked 3, BM017, dJ545K15.2, GASP6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Armcx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Armadillo/beta-catenin-like repeat
- Armadillo/beta-catenin-like repeats
- protein binding
- Armadillo-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- Huntington disease
- primitive neuroectodermal neoplasm
- Turner syndrome
- germ cell cancer
role in cell
- organization
- transactivation in
- axonal transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Nucleus
- Mitochondria
- cytosol
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Armcx3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization
- axon transport of mitochondrion
- positive regulation of transcription from RNA polymerase II promoter
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein binding