Zbtb11 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Is expressed in central nervous system; genitourinary system; and inner ear. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 69. Orthologous to human ZBTB11 (zinc finger and BTB domain containing 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zbtb11 |
| Official Name | zinc finger and BTB domain containing 11 [Source:MGI Symbol;Acc:MGI:2443876] |
| Ensembl ID | ENSMUSG00000022601 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 11 |
| Synonyms | 9230110G02Rik, MRT69, zinc finger and BTB domain containing 11, ZNF913, ZNF-U69274 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zbtb11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Integrase zinc binding domain
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- Zinc-finger double domain
- BTB/POZ domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- COVID-19
- autosomal recessive mental retardation type 69
- non-insulin-dependent diabetes mellitus
- Alzheimer disease
- major depression
- bladder cancer
regulates
role in cell
- proliferation
- apoptosis
- cisplatin sensitivity
- downregulation in
- JG-231 sensitivity
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zbtb11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity