Rpl7 Gene Summary [Mouse]
A structural constituent of ribosome. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to act upstream of or within translation. Located in cytoplasm and ribosome. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in several structures, including brain; early conceptus; female reproductive system; and liver. Orthologous to human RPL7 (ribosomal protein L7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Rpl7 |
| Official Name | ribosomal protein L7 [Source:MGI Symbol;Acc:MGI:98073] |
| Ensembl ID | ENSMUSG00000043716 |
| Bio databases IDs | |
| Aliases | ribosomal protein L7 |
| Synonyms | humL7-1, L7, Ribosomal protein l7, Rpl7a, Surf-3, uL30 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpl7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- mRNA binding
- 5S rRNA binding
- protein binding
- identical protein binding
- DNA binding
- Ribosomal L30 N-terminal domain
- RNA binding
- bZIP domain
- 60S ribosomal protein uL30, eukaryotic form
- Ribosomal protein L30p/L7e
- structural constituent of ribosome
- Ribosomal_L30_like
Pathways
Biological processes and signaling networks where the Rpl7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- chronic kidney disease
- non-small cell lung cancer
- hearing loss
- myelodysplastic syndrome
- non-small cell lung carcinoma
regulates
- ribosomal large subunit
role in cell
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cellular membrane
- ribosome
- Endoplasmic Reticulum
- sarcomere
- polysomes
- cytosol
- nucleoli
- nuclear envelope
- synapse
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpl7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- ribosomal large subunit biogenesis
- cytoplasmic translation
- rRNA processing
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- postsynaptic density
- cytosolic ribosome
- focal adhesion
- cytoplasm
- membrane
- cytosol
- cytosolic large ribosomal subunit
- nucleolus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein binding
- RNA binding
- structural constituent of ribosome
- mRNA binding