Ddx1 Gene Summary [Mouse]
Enables double-stranded RNA binding activity. Involved in positive regulation of canonical NF-kappaB signal transduction and positive regulation of myeloid dendritic cell cytokine production. Acts upstream of or within response to exogenous dsRNA and response to virus. Located in cytoplasmic stress granule; cytosol; and mitochondrion. Is expressed in several structures, including 1st branchial arch; blastocyst; central nervous system; early embryo; and genitourinary system. Orthologous to human DDX1 (DEAD-box helicase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddx1 |
| Official Name | DEAD box helicase 1 [Source:MGI Symbol;Acc:MGI:2144727] |
| Ensembl ID | ENSMUSG00000037149 |
| Bio databases IDs | |
| Aliases | DEAD box helicase 1 |
| Synonyms | DBP-RB, DEAD-box helicase 1, DEAD-box protein 1, UKVH5d |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPRY domain
- nuclease
- helicase
- helicase superfamily c-terminal domain
- transcription cofactor
- poly(A) binding protein
- chromatin binding
- enzyme
- protein binding
- DNA dependent ATPase
- Helicase conserved C-terminal domain
- RNA helicase
- RNA dependent ATPase
- double-stranded RNA binding
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- organismal death
- Huntington disease
- neuroblastoma
- neuroblastoma formation
role in cell
- expression in
- damage in
- activation in
- accumulation in
- cisplatin sensitivity
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
- nuclear foci
- nucleoplasm
- nuclear bodies
- Cajal bodies
- stress granule
- cleavage bodies
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleic acid metabolic process
- positive regulation of myeloid dendritic cell cytokine production
- innate immune response
- response to exogenous dsRNA
- DNA duplex unwinding
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- defense response to virus
- tRNA splicing, via endonucleolytic cleavage and ligation
- regulation of translational initiation
- spliceosomal complex assembly
- double-strand break repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- cytoplasm
- mitochondrion
- membrane
- cytosol
- cleavage body
- nucleoplasm
- tRNA-splicing ligase complex
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- poly(A) RNA binding
- chromatin binding
- DNA binding
- ATP binding
- RNA binding
- transcription cofactor activity
- protein binding
- RNA helicase activity
- double-stranded RNA binding
- exonuclease activity
- nuclease activity
- DNA/RNA helicase activity