Rabl2 Gene Summary [Mouse]
Enables GTP binding activity. Involved in photoreceptor cell morphogenesis. Acts upstream of or within cilium assembly; flagellated sperm motility; and single fertilization. Located in sperm midpiece. Part of intraciliary transport particle B. Is expressed in several structures, including eye; genitourinary system; gut; nervous system; and respiratory system. Orthologous to several human genes including RABL2B (RAB, member of RAS oncogene family like 2B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rabl2 |
| Official Name | RAB, member RAS oncogene family-like 2 [Source:MGI Symbol;Acc:MGI:1915958] |
| Ensembl ID | ENSMUSG00000022621 |
| Bio databases IDs | |
| Aliases | RAB, member RAS oncogene family-like 2 |
| Synonyms | 1110031N17Rik, Rabl2, Rabl2a, RAB, member of RAS oncogene family like 2, RAB, member of RAS oncogene family like 2B, RAB, member RAS oncogene family-like 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rabl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- small GTP-binding protein domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- Rab subfamily of small GTPases
- GTPase
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- basal bodies
- centrosome
- centriole
- sperm midpiece
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rabl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- intraflagellar transport
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- pericentriolar material
- cilium basal body
- centriole
- cytoplasm
- endomembrane system
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity