P2rx6 Gene Summary [Mouse]
Predicted to enable extracellularly ATP-gated monoatomic cation channel activity. Predicted to be involved in calcium ion transmembrane transport. Located in neuronal cell body and nucleus. Is expressed in central nervous system; heart; parathyroid gland; reproductive system; and respiratory system. Orthologous to human P2RX6 (purinergic receptor P2X 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | P2rx6 |
| Official Name | purinergic receptor P2X, ligand-gated ion channel, 6 [Source:MGI Symbol;Acc:MGI:1337113] |
| Ensembl ID | ENSMUSG00000022758 |
| Bio databases IDs | |
| Aliases | purinergic receptor P2X, ligand-gated ion channel, 6 |
| Synonyms | P2RXL1, P2X6, P2XM, purinergic receptor P2X 6, purinergic receptor P2X, ligand-gated ion channel, 6, Rnap2x6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse P2rx6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- ATP P2X receptor
- channel/pore class transporter
- ATP-gated cation channel
- protein binding
- ion channel
- transmembrane receptor
Pathways
Biological processes and signaling networks where the P2rx6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell junction
- Cytoplasm
- cellular membrane
- Nucleus
- endoplasmic reticulum membrane
- synaptic membrane
- dendritic spines
- perikaryon
- dendrites
- postsynaptic density
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse P2rx6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- purinergic nucleotide receptor signaling pathway
- signal transduction
- response to ATP
- muscle contraction
- calcium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- dendritic spine
- cell junction
- receptor complex
- neuronal cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- extracellular ATP-gated cation channel activity
- ATP binding
- channel activity
- transmembrane signaling receptor activity
- purinergic nucleotide receptor activity