P2rx5 Gene Summary [Mouse]
Enables extracellularly ATP-gated monoatomic cation channel activity. Predicted to be involved in several processes, including positive regulation of calcium ion import across plasma membrane; regulation of skeletal muscle tissue regeneration; and response to ATP. Predicted to act upstream of or within cell surface receptor signaling pathway. Predicted to be located in cytosol and plasma membrane. Is expressed in several structures, including forelimb bud; nervous system; neural ectoderm; olfactory epithelium; and retina. Orthologous to human P2RX5 (purinergic receptor P2X 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | P2rx5 |
| Official Name | purinergic receptor P2X, ligand-gated ion channel, 5 [Source:MGI Symbol;Acc:MGI:2137026] |
| Ensembl ID | ENSMUSG00000005950 |
| Bio databases IDs | |
| Aliases | purinergic receptor P2X, ligand-gated ion channel, 5 |
| Synonyms | LRH-1, P2X5, P2X5R, purinergic receptor P2X 5, purinergic receptor P2X, ligand-gated ion channel, 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse P2rx5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- anion channel
- ATP P2X receptor
- channel/pore class transporter
- ATP binding
- ligand-gated ion channel
- ATP-gated cation channel
- protein binding
- identical protein binding
- voltage-gated ion channel
- ion channel
- transmembrane receptor
Pathways
Biological processes and signaling networks where the P2rx5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Down syndrome
- rotator cuff injury
- diabetic nephropathy
regulates
- phosphatidylserine
- IL10
- chloride
- cation
role in cell
- number
- exposure in
- blebbing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- cytosol
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse P2rx5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of calcium-mediated signaling
- regulation of excitatory postsynaptic membrane potential
- osteoclast maturation
- purinergic nucleotide receptor signaling pathway
- response to ATP
- signal transduction
- nervous system development
- calcium ion transmembrane transport
- positive regulation of calcium ion transport into cytosol
- chloride transport
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- extracellular ATP-gated cation channel activity
- ATP binding
- ion channel activity
- transmembrane signaling receptor activity
- ATP-gated ion channel activity
- purinergic nucleotide receptor activity