Snx4 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol-3-phosphate binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including endocytic recycling; positive regulation of autophagosome assembly; and positive regulation of histamine secretion by mast cell. Is active in presynaptic endosome. Orthologous to human SNX4 (sorting nexin 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Snx4 |
| Official Name | sorting nexin 4 [Source:MGI Symbol;Acc:MGI:1916400] |
| Ensembl ID | ENSMUSG00000022808 |
| Bio databases IDs | |
| Aliases | sorting nexin 4 |
| Synonyms | 1810036H14Rik, ATG24B, sorting nexin 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Snx4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- insulin receptor binding
- epidermal growth factor receptor binding
- coiled-coil domain
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- receptor binding
- Bin/Amphiphysin/Rvs domain
- PX domain
- phosphatidylinositol binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cellular membrane
- Plasma Membrane
- endosomes
- cytosol
- endosomal membrane
- recycling endosomes
- early endosomes
- late endosomes
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Snx4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
- positive regulation of autophagic vacuole assembly
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- cytoplasmic dynein complex
- early endosome
- cytoplasm
- membrane
- SNARE complex
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol binding
- epidermal growth factor receptor binding
- phosphatidylinositol-3-phosphate binding
- insulin receptor binding