Bin1 Gene Summary [Mouse]
Enables aspartic-type endopeptidase inhibitor activity; signaling adaptor activity; and tau protein binding activity. Involved in several processes, including negative regulation of amyloid precursor protein catabolic process; negative regulation of cation transmembrane transport; and regulation of heart contraction. Acts upstream of or within muscle cell differentiation and quinolinate biosynthetic process. Located in several cellular components, including T-tubule; dendrite; and nuclear envelope. Is active in glutamatergic synapse; postsynapse; and presynapse. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; heart; and musculature. Human ortholog(s) of this gene implicated in breast carcinoma; centronuclear myopathy 2; and prostate adenocarcinoma. Orthologous to human BIN1 (bridging integrator 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bin1 |
| Official Name | bridging integrator 1 [Source:MGI Symbol;Acc:MGI:108092] |
| Ensembl ID | ENSMUSG00000024381 |
| Bio databases IDs | |
| Aliases | bridging integrator 1 |
| Synonyms | AMPH2, Amphiphysin 2m, AMPHL, bridging integrator 1, CNM2, SH3P9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bin1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- aspartic protease inhibitor
- protease binding
- protein binding activity, bridging
- enzyme binding
- clathrin binding
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- Sh3 domain binding motif
- Src Homology 3 domain superfamily
- actin filament binding
- amphiphysin II insert domain
- binding protein
- tau protein binding
- Myc binding domain
- Domain of Unknown Function (DUF959)
- chaperone binding
- BAR domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ulcerative colitis
- epithelial cancer
- tauopathy
- centronuclear myopathy
- Alzheimer disease
- ventricular arrhythmia
- septic shock
- cachexia
- centronuclear myopathy type 2
role in cell
- expression in
- production in
- growth
- apoptosis
- differentiation
- morphology
- phosphorylation in
- migration
- cell death
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- membrane fraction
- glutaminergic synapse
- axon component
- cytoskeleton
- Cytoplasm
- presynaptic regions
- postsynaptic region
- lipid tubules
- cellular membrane
- actin cytoskeleton
- Plasma Membrane
- vesicles
- lysosome
- Endoplasmic Reticulum
- microtubules
- cell-cell contacts
- cytosol
- nucleoplasm
- nuclear envelope
- nodes of Ranvier
- synaptic vesicles
- nerve ending
- synapse
- I band
- Z line
- early endosomes
- late endosomes
- transverse tubules
- clathrin-coated pits
- axons
- dendrites
- axon terminals
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bin1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T-tubule organization
- cytoskeleton organization
- positive regulation of endocytosis
- lipid tube assembly
- positive regulation of astrocyte differentiation
- endosome to lysosome transport
- regulation of neuron differentiation
- endocytosis
- nucleus organization
- negative regulation of transcription from RNA polymerase II promoter
- synaptic vesicle endocytosis
- positive regulation of actin filament polymerization
- positive regulation of apoptotic process
- regulation of heart rate by cardiac conduction
- nucleus localization
- regulation of cell cycle process
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- cerebellar mossy fiber
- lipid tube
- plasma membrane
- axon terminus
- nuclear envelope
- T-tubule
- dendrite
- Z disc
- nucleus
- initial segment
- endosome
- cytoskeleton
- varicosity
- cytoplasm
- membrane
- actin cytoskeleton
- cytosol
- vesicle
- I band
- node of Ranvier
- axon
Molecular Function
What the gene product does at the molecular level
- RNA polymerase binding
- actin filament binding
- identical protein binding
- protein binding
- aspartic-type endopeptidase inhibitor activity
- GTPase binding
- tau protein binding
- chaperone binding
- protease binding
- clathrin binding
- phospholipid binding