Atxn2 Gene Summary [Mouse]
Predicted to enable epidermal growth factor receptor binding activity and mRNA binding activity. Acts upstream of or within several processes, including homeostasis of number of cells; neuromuscular process; and neuron differentiation. Located in perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system; sensory organ; and submandibular gland primordium. Used to study spinocerebellar ataxia type 2. Human ortholog(s) of this gene implicated in late onset Parkinson's disease and spinocerebellar ataxia type 2. Orthologous to human ATXN2 (ataxin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Atxn2 |
| Official Name | ataxin 2 [Source:MGI Symbol;Acc:MGI:1277223] |
| Ensembl ID | ENSMUSG00000042605 |
| Bio databases IDs | |
| Aliases | ataxin 2 |
| Synonyms | 9630045M23RIK, Ataxin-2, ATX2, AW544490, SCA2, TNRC13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atxn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sm and related proteins
- Ataxin 2 SM domain
- Ataxin-2 C-terminal region
- epidermal growth factor receptor binding
- polyglutamine repeat
- glutamine repeat domain
- LsmAD domain
- protein binding
- Sh3 domain binding motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- gastroesophageal reflux
- neurological disorder
- autoimmune thyroid disease
- inflammatory bowel disease
- heart disease
- rheumatoid arthritis
- insulin-dependent diabetes mellitus
- systemic lupus erythematosus
role in cell
- loss
- cell death
- apoptosis
- activation in
- quantity
- expression in
- formation
- phosphorylation in
- accumulation in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- Golgi Apparatus
- cytosol
- trans Golgi network
- stress granule
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atxn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- stress granule assembly
- RNA metabolic process
- negative regulation of receptor internalization
- cytoplasmic mRNA processing body assembly
- RNA transport
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- perinuclear region of cytoplasm
- cytoplasmic stress granule
- cytoplasm
- membrane
- cytosol
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- epidermal growth factor receptor binding
- mRNA binding