Dop1b Gene Summary [Mouse]
Predicted to be involved in cognition and embryonic pattern specification. Predicted to be located in early endosome membrane. Predicted to be active in endosome and trans-Golgi network. Is expressed in several structures, including early conceptus; genitourinary system; gut; nervous system; and sensory organ. Orthologous to human DOP1B (DOP1 leucine zipper like protein B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dop1b |
| Official Name | DOP1 leucine zipper like protein B [Source:MGI Symbol;Acc:MGI:1917278] |
| Ensembl ID | ENSMUSG00000022946 |
| Bio databases IDs | |
| Aliases | DOP1 leucine zipper like protein B |
| Synonyms | 0610038M01Rik, 21orf5, 2610510B01Rik, C21orf5, DOP1 leucine zipper like protein B, DOPEY2, mKIAA0933, RGD1306097 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dop1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Dopey, N-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- cervical cancer
- neoplasia
- COVID-19
- arthralgia
- Down syndrome
- cervical small cell carcinoma
- extrapulmonary small cell cancer
- epithelial uterine cancer
regulated by
- budesonide
role in cell
- apoptosis
- expression in
- organization
- degradation in
- ubiquitination in
- cisplatin resistance
- cisplatin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dop1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cognition
- embryonic pattern specification
- protein transport
- endoplasmic reticulum organization
- Golgi to endosome transport
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- trans-Golgi network
- endosome
- extracellular vesicular exosome
- cytosol
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding