Sncg Gene Summary [Mouse]
Predicted to enable alpha-tubulin binding activity; beta-tubulin binding activity; and cuprous ion binding activity. Involved in protein secretion. Acts upstream of or within several processes, including adult locomotory behavior; chemical synaptic transmission; and regulation of secretion by cell. Located in axon; cytoplasm; and neuronal cell body. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; eye; and hemolymphoid system gland. Used to study amyotrophic lateral sclerosis type 1. Human ortholog(s) of this gene implicated in Lewy body dementia. Orthologous to human SNCG (synuclein gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sncg |
| Official Name | synuclein, gamma [Source:MGI Symbol;Acc:MGI:1298397] |
| Ensembl ID | ENSMUSG00000023064 |
| Bio databases IDs | |
| Aliases | synuclein, gamma |
| Synonyms | BCSG1, breast cancer-specific protein 1, Gamma-syn, Persyn, SR, synuclein gamma, synuclein, gamma, Synuclein γ, synuclein, γ, γ-syn |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sncg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- alpha-tubulin binding
- Synuclein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- metastasis
- neoplasia
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
- organismal death
- bladder cancer
- Parkinson disease
role in cell
- expression in
- phosphorylation in
- apoptosis
- formation
- formation in
- invasion by
- growth
- activation in
- proliferation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- centrosome
- Golgi Apparatus
- cytosol
- growth cone
- perikaryon
- axons
- axon terminals
- presynaptic terminals
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sncg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dopamine secretion
- regulation of neurotransmitter secretion
- synapse organization
- synaptic vesicle endocytosis
- synaptic transmission
- adult locomotory behavior
- protein secretion
Cellular Component
Where in the cell the gene product is active
- centrosome
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- spindle
- neuronal cell body
- axon terminus
Molecular Function
What the gene product does at the molecular level
- protein binding