Bub1b Gene Summary [Mouse]
Predicted to enable protein kinase activity. Acts upstream of or within metaphase/anaphase transition of mitotic cell cycle and protein localization to chromosome, centromeric region. Located in kinetochore. Part of outer kinetochore. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study mosaic variegated aneuploidy syndrome 1. Human ortholog(s) of this gene implicated in colorectal cancer and mosaic variegated aneuploidy syndrome 1. Orthologous to human BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bub1b |
| Official Name | BUB1B, mitotic checkpoint serine/threonine kinase [Source:MGI Symbol;Acc:MGI:1333889] |
| Ensembl ID | ENSMUSG00000040084 |
| Bio databases IDs | |
| Aliases | BUB1B, mitotic checkpoint serine/threonine kinase |
| Synonyms | Bub1A, BUB1beta, BUB1B, mitotic checkpoint serine/threonine kinase, BUB1 mitotic checkpoint serine/threonine kinase B, BUBR1, hBUBR1, MAD3, MAD3L, MVA1, SSK1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bub1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- protein kinase
- Mad3/BUB1 homology region 1
- destruction box
- Protein Kinases, catalytic domain
- BUB3 binding domain
- Phe box
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- small cell lung cancer
- tumorigenesis
- lung squamous cell carcinoma
- squamous cell lung cancer
- liver cancer
- epithelial cancer
- glomerulosclerosis
- organismal death
role in cell
- cell death
- accumulation
- apoptosis
- cell viability
- quantity
- growth
- survival
- missegregation
- senescence
- spindle checkpoint
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- Cytoplasm
- perinuclear region
- basal bodies
- cytosol
- chromosome
- mitotic spindle
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bub1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- cell division
- apoptotic process
- mitotic metaphase/anaphase transition
- meiotic sister chromatid cohesion, centromeric
- protein localization to chromosome, centromeric region
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- perinuclear region of cytoplasm
- cytoplasm
- anaphase-promoting complex
- spindle
- cytosol
- mitotic checkpoint complex
- kinetochore
- condensed chromosome outer kinetochore
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity