Map2k6 Gene Summary [Mouse]
Enables MAP kinase kinase activity. Involved in bone development; negative regulation of cold-induced thermogenesis; and osteoblast differentiation. Acts upstream of or within several processes, including MAPK cascade; cardiac muscle contraction; and positive regulation of MAP kinase activity. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Orthologous to human MAP2K6 (mitogen-activated protein kinase kinase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map2k6 |
| Official Name | mitogen-activated protein kinase kinase 6 [Source:MGI Symbol;Acc:MGI:1346870] |
| Ensembl ID | ENSMUSG00000020623 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase 6 |
| Synonyms | MAPKK6, Mapk kinase 6, MEK6, mitogen-activated protein kinase kinase 6, MKK6, MKK6BE, PRKMK6, SAPKK-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Map2k6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein threonine/tyrosine kinase
- Protein kinase (unclassified specificity)
- protein kinase binding
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- MAPK binding site
- enzyme
- protein binding
- Protein kinase domain
- identical protein binding
- phosphorylation site
- kinase
- MAP kinase kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- docking domain
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
- LF interacting region
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Map2k6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- BER pathway
- CD27 Signaling in Lymphocytes
- CD40 Signaling
- Endocannabinoid Developing Neuron Pathway
- ErbB Signaling
- FGF Signaling
- GADD45 Signaling
- IL-10 Signaling
- IL-15 Production
- LPS-stimulated MAPK Signaling
- Melatonin Signaling
- Molecular Mechanisms of Cancer
- Neurotrophin/TRK Signaling
- NF-κB Signaling
- Polyamine Regulation in Colon Cancer
- RANK Signaling in Osteoclasts
- Reelin Signaling in Neurons
- Role of IL-17A in Arthritis
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Th1 Pathway
- Toll-like Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- reperfusion injury
- osteoarthritis
- septic shock
- neonatal late-onset sepsis
- fibrosis
- hip osteoarthritis
- dwarfism
- systemic autoimmune syndrome
- osteoporosis
role in cell
- proliferation
- tubulation
- phosphorylation in
- apoptosis
- expression in
- quantity
- binding in
- activation in
- production in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Map2k6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to sorbitol
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
- p38MAPK cascade
- stress-activated protein kinase signaling cascade
- signal transduction
- cellular senescence
- signal transduction in response to DNA damage
- ovulation cycle process
- positive regulation of MAPK cascade
- response to xenobiotic stimulus
- cardiac muscle contraction
- bone development
- positive regulation of prostaglandin secretion
- MAPK cascade
- response to ischemia
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of apoptotic process
- positive regulation of protein phosphorylation
- apoptotic process
- osteoblast differentiation
- regulation of cell cycle
- stress-activated MAPK cascade
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- protein tyrosine kinase activity
- protein binding
- MAP kinase kinase activity
- protein serine/threonine kinase activity