Plaur Gene Summary [Mouse]
Predicted to enable enzyme binding activity; protein domain specific binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including positive regulation of homotypic cell-cell adhesion; positive regulation of release of cytochrome c from mitochondria; and regulation of signal transduction. Located in plasma membrane. Part of serine-type endopeptidase complex. Is expressed in several structures, including decidua; early conceptus; and spleen. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human PLAUR (plasminogen activator, urokinase receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plaur |
| Official Name | plasminogen activator, urokinase receptor [Source:MGI Symbol;Acc:MGI:97612] |
| Ensembl ID | ENSMUSG00000046223 |
| Bio databases IDs | |
| Aliases | plasminogen activator, urokinase receptor |
| Synonyms | CD87, Par, plasminogen activator, urokinase receptor, Plaur3, U-PAR, uPAR-2, UPAR-3, Urinary plasminogen activator receptor 2, URKR, UROKINASE R, Urokinase-Type Plasminogen Activator Receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plaur often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- soluble domain
- urokinase binding domain
- uPA binding domain
- signaling receptor activity
- ectodomain
- enzyme binding
- linker domain
- protein domain specific binding
- protein binding
- receptor binding
- U-plasminogen activator receptor
- domain 2
- GPI anchor
- TFP
- loop domain
- transmembrane receptor
- glycosylphosphatidylinositol anchor sequence
Pathways
Biological processes and signaling networks where the Plaur gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- neoplasia
- metastasis
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
role in cell
- formation
- phosphorylation in
- expression in
- apoptosis
- activation in
- proliferation
- function
- growth
- loss
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- cell surface
- perinuclear membrane
- Extracellular Space
- cellular membrane
- specific granule membrane
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- apical membrane
- basolateral membrane
- dendritic spines
- early endosomes
- membrane rafts
- cellular protrusions
- filopodia
- cell membrane leading edge
- perikaryon
- dendrites
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plaur gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of homotypic cell-cell adhesion
- signal transduction
- positive regulation of release of cytochrome c from mitochondria
- regulation of proteolysis
- regulation of fibrinolysis
- positive regulation of epidermal growth factor receptor signaling pathway
- positive regulation of DNA binding
- blood coagulation
- chemotaxis
- negative regulation of apoptotic process
- positive regulation of protein phosphorylation
- regulation of cell adhesion
- regulation of plasminogen activation
- negative regulation of intrinsic apoptotic signaling pathway
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- focal adhesion
- membrane
- external side of plasma membrane
- extrinsic to membrane
- extracellular region
- cell projection
- plasma membrane
- specific granule membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- signaling receptor activity
- U-plasminogen activator receptor activity
- receptor binding
- enzyme binding