Npy2r Gene Summary [Mouse]
Enables peptide YY receptor activity. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Located in non-motile cilium. Is active in cilium. Is expressed in central nervous system; dorsal root ganglion; eye; and metanephros. Human ortholog(s) of this gene implicated in Huntington's disease; morbid obesity; and obesity. Orthologous to human NPY2R (neuropeptide Y receptor Y2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Npy2r |
| Official Name | neuropeptide Y receptor Y2 [Source:MGI Symbol;Acc:MGI:108418] |
| Ensembl ID | ENSMUSG00000028004 |
| Bio databases IDs | |
| Aliases | neuropeptide Y receptor Y2 |
| Synonyms | LOC100360265, neuropeptide Y receptor Y2, Y2R |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Npy2r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- internalization targeting signal
- peptide YY receptor
- Cholecystokinin A receptor, N-terminal
- signaling receptor activity
- neuropeptide Y receptor
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- calcium channel regulator
Pathways
Biological processes and signaling networks where the Npy2r gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- FAK Signaling
- G Protein Signaling Mediated by Tubby
- G-Protein Coupled Receptor Signaling
- GPCR-Mediated Integration of Enteroendocrine Signaling Exemplified by an L Cell
- Molecular Mechanisms of Cancer
- Phagosome Formation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- weight gain
- morbid obesity
- weight loss
- seizures
- hyperphagia
role in cell
- production in
- number
- activation
- function
- maturation
- activity
- abnormal morphology
- elevation in
- synaptic transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- non-motile cilium
- cilia
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Npy2r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cardiac left ventricle morphogenesis
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- neuropeptide signaling pathway
- locomotory behavior
- outflow tract morphogenesis
Cellular Component
Where in the cell the gene product is active
- cilium
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- peptide YY receptor activity
- signaling receptor activity
- calcium channel regulator activity
- neuropeptide Y receptor activity