Lpar6 Gene Summary [Mouse]
Predicted to enable lysophosphatidic acid receptor activity. Acts upstream of or within blastocyst hatching. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Human ortholog(s) of this gene implicated in hypotrichosis 8. Orthologous to human LPAR6 (lysophosphatidic acid receptor 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lpar6 |
| Official Name | lysophosphatidic acid receptor 6 [Source:MGI Symbol;Acc:MGI:1914418] |
| Ensembl ID | ENSMUSG00000033446 |
| Bio databases IDs | |
| Aliases | lysophosphatidic acid receptor 6 |
| Synonyms | 2610302I02Rik, ARWH1, HYPT8, LAH3, LOC684663, LPA-6, lysophosphatidic acid receptor 6, P2RY5, P2Y5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lpar6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Lpar6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- autosomal recessive hypotrichosis
- organismal death
- paroxysmal nocturnal hemoglobinuria
- autosomal recessive woolly hair 1
- Alzheimer disease
regulates
- guanosine 5'-O-(3-thiotriphosphate)
- GNA13
role in cell
- contraction
- extravasation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lpar6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rho protein signal transduction
- blastocyst hatching
- phospholipase C-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- lysophosphatidic acid receptor activity
- protein binding